Nitroxinil is a drug used in animals like cattle, goats, sheep etc.., to remove flukes and worms. It is one of the veterinary medicine. Its chemical class is halogenated phenol. It is used as a main parasitic controller for controlling liver flukes and nematodes. It is a less toxic and oral type of medicine and the dosage amount will be depending on each country. Nitroxinil came into the market by the year of 1960. May and Baker introduced one of the low spectrum nematicide which we get in the form of injections which is not preferable to any other pets. This drug is highly effective for liver flukes, oesophagostomum spp, and oestrus ovisparafilaria bovicola not only kills the gems during the period of treatment but also helps to protect in future period of time. We may say it as re-infestation. It works effectively only against roundworms and it will not work against lung worms like dictyocaulus spp, tape worms and also eye worms like thelazia spp. 97% of plasma proteins contents in Nitroxinil which are higher than normal one. It helps to excreted in liver.
Mechanism of Nitroxinil
Nitroxinil is also called as nitroxynil which helps the mitochondria to disturb the production fuel in the cell in order to avoid future damages and impairs parasite mobility. The main toxic symptoms that are seen here is high fever and breathing, increased excitability. The usage amount of drugs to sheep and cattle is greater than or equal to 40mg/kg. For adult cattle it is greater than or equal to 55mg/kg is the normal dosage level. Like all the other drugs, nitroxinil also has certain side effects like swelling, skin problems and hair stains yellow in color. These types of drugs are not advisable to use on fish. It belongs to the halogenated phenols which we mention chemical class. Always ask the veterinary doctor before using it on your pet. Wrong usage of dose can give the terrible pain to your pet.
Extreme Impact Details
Electrochemical behavior of nitroxynil drug was studied by Britton-Robinson. According to him containing 20% ethanol should be controlled and avoided to animals. Nitroxynil activity is against adult resistant and the egg count of the infected cattle’s will be reduced due to nitroxinil. Efficacy of rafoxanide and triclabendazole is against immature pets. It affects the intro reduction. Liver flukes appear when the pets were not getting treated on time. In United States these drugs are not preferable to use due to efficiency issues. Only in some country these medicines were approved by the government. The generic names for nitroxinil are nitroxynil (IS), nitroxinil pour usage veterinaire nitroxinil (PH: BP vet), nitroxinil (OS: DCF BAN), nitroxynil Eyulumine (IS), nitroxinil with N-ethylglucamine. The brand name which this drug uses is Nitromec, Trodax, Wirecide, Combat Nitromec and Dovenix.
The dosage of medicine depends on the weight of the animal. For 25kg we should use 1ml, second injection should be given 3 weeks later time to the first injection. Just like other drugs this is also preferred to store in cool and dark places. Once the cattle is injected with the medicine then the meat of that particular cattle should not be taken for next sixty days and if it is sheep then we should avoid it for 40 nine days even milk also not advisable to take.
Lasa Laboratory Pvt Ltd leading manufacturing of veterinary active pharmaceutical ingredient in Maharashtra India. We mainly focus to manufacturing of Albendazole, Fenbendazole, Oxfendazole, Nitroxynil, Toldimphos sodium, Cyromazine, Halquinol, Oxyclozanide, Ricobendazole etc